Associations
The primary goal of this study was to analyze urinary Na + , K + and the Na + :K + excretion ratio, for associations with changes in systolic blood pressure (SBP) in participants from the DASH–Sodium trial during the initial screening period in which participants were consuming their regular diet without dietary intervention. The secondary goals of this study were to investigate: (a) the impact of the salt sensitivity of blood pressure on these responses and (b) the impact of the DASH–Sodium dietary intervention, which lowers SBP and increases dietary K + intake, on these potential associations. Our analysis reports that in the DASH–Sodium study cohort: (1) a daily excretion of <1 g K + /day is associated with elevated SBP, (2) urinary K + excretion of >1 g/day does not correlate with a reduction in SBP and, (3) a reduction in the urinary Na + :K + excretion ratio is not associated with lower SBP irrespective of the salt sensitivity of blood pressure. Collectively our data support the recent DRI recommendation not to propose a DRI for K + and suggest that further evidence is required to support the establishment of a Na + /K + excretion ratio that would reduce SBP in the general population.
Analytical parameters
Suggest SBP relative to urinary sodium in order to potassium (Na + /K + ) excretion proportion during tests along with weight reduction intervention away from Fat reduction Solutions to Stop Hypertension (DASH) large sodium (HS) and lower salt (LS) eating plan in the (a) salt painful and sensitive (letter = 71), (b) sodium resistant (n = 119) individuals, viewpoints shown because the mean ± SD.
Significantly, we observed no association between the urinary Na + :K + ratio and SBP on the DASH HS or DASH LS dietary intervention in either SS (DASH HS R 2 = 0.04, DASH LS R 2 = 0.02) or SR (DASH HS R 2 = 0.04, DASH LS R 2 = 0.00002) participants (Fig. 5a, b). The DASH dietary intervention significantly increased the number of participants in both SS and SR groups with a urinary Na + :K + ratio of <1 on both the HS and LS diet. However, the urinary Na + :K + had no impact on SBP within dietary intake groups (Fig. 6a, b). Further, when expressed as a frequency distribution histogram the change in SBP from the DASH HS to LS dietary intervention exhibits a profound leftward shift in the SS group compared to SR group (Fig. 7a). In contrast, the frequency distribution histogram for change in the urinary Na + :K + ratio from the DASH HS to LS dietary intervention shows no difference in the Gaussian curve and distribution between SS and SR participants (Fig. 7b).
Next, numerous research has recommended the blood pressure avoidance evoked of the K + intake could be determined by losing weight Na + intake [28, 29]. Within our study of the Dashboard-Salt dataset i noticed zero http://datingranking.net/pl/hiki-recenzja connection that have urinary K + removal and you can SBP, during the patient testing head to or throughout Dashboard losing weight input when Na + consumption are altered, indicating a freedom of your results of Na + and you may K + to the SBP within study. The brand new 2019 DRI Statement determined that there is shortage of evidence to the the effects of K + into the hypertension and you will didn’t establish a good DRI out-of K + . The research secure the 2019 DRI Statement and you can shows that weight reduction K + supplements will most likely not somewhat eradicate blood pressure about general society.
Conclusion
Stamler J, Flower Grams, Stamler R, Elliott P, Dyer A beneficial, Marmot Meters. INTERSALT data results. Personal health and health care ramifications. Blood pressure level. 1989;–7.
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